Pharmacology and Pharmaceutics Instruments

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Metabolic cages are specialized enclosures used in scientific research to measure various aspects of metabolism in rats and mice. These cages are designed to allow researchers to monitor factors such as: Food and water intake: Metabolic cages typically have separate compartments for food and water, allowing precise measurement of consumption over time. Urine and feces collection: They are equipped with collection devices to gather urine and feces, enabling the measurement of metabolites, hormone levels, and other biochemical markers. Activity monitoring: Many metabolic cages are equipped with sensors or cameras to track the animal's movement and activity levels, providing insights into energy expenditure and overall metabolic rate. Respiratory measurements: Some advanced metabolic cages can also measure oxygen consumption and carbon dioxide production, which are important indicators of metabolic activity. Overall, metabolic cages provide a controlled environment for studying the metabolic processes of rodents under various experimental conditions, helping researchers understand aspects of nutrition, physiology, pharmacology, and disease.

Milton Enterprises Manufacturing reinvented Semi Automatic Sampling System with Diffusion Cell Apparatus is used to study of trans-dermal properties of pharmaceutical substances in the pharmacy colleges, medical research institutes and pharmaceutical industries. Having 6â??stages & 8-stages Motorless Stirring Drives, user can drive each stirrer stage at different RPM from 100 RPM to 1000 RPM, diffusion cell apparatus provided with water circulation system to maintain uniform temperature throughout all diffusion cells, water circulation system consists of water circulation pump which circulate water to all diffusion cells, and get back to maintain temperature.

The Conditioned Avoidance Test Apparatus is a behavioral experimental setup used to study learning, memory, and anxiety in animals, typically rodents. The apparatus generally consists of a chamber divided into two or more compartments. One compartment is designated as the "safe" zone, while the other is associated with an aversive stimulus, such as a mild electric shock. During the test, the animal learns to associate certain cues (such as a light or sound) with the impending aversive stimulus. The animal's ability to avoid the aversive compartment in response to these cues is measured to assess its learning and memory capabilities. This apparatus is commonly used in research on neuropharmacology, cognitive function, and the effects of various drugs or treatments on anxiety-related behaviors.

The Hole Board Apparatus is a widely used experimental setup in behavioral neuroscience for assessing exploratory behavior and anxiety in rodents, particularly mice and rats. Here is a brief description:

The Vogel Test (Lick-O-Meter) is a valuable tool in pharmacological research for assessing the anxiolytic and anxiogenic effects of various compounds in rodents. By measuring changes in licking behavior under a conflict situation, researchers can gain insights into the anxiety-modulating properties of the test compounds. The procedure involves baseline measurement, administration of test compounds, a conflict session with shocks, and detailed data analysis to interpret the behavioral outcomes.

An incubator is a crucial piece of equipment used in laboratories to create and maintain controlled environments for biological cultures, cell lines, and microorganisms. Here's a concise overview: - **Purpose**: Incubators provide a stable and controlled environment with regulated temperature, humidity, and often CO2 levels, ideal for the growth and experimentation of biological samples. - **Applications**: They are used extensively in microbiology, cell biology, biotechnology, and pharmaceutical research for tasks such as cell culture, microbial culturing, embryo development, and biochemical assays. - **Key Features**: Modern incubators typically include programmable temperature settings, humidity control systems, HEPA filtration for sterile air circulation, and often CO2 control for maintaining physiological pH levels in cell cultures. - **Types**: Incubators vary in size and design, from small benchtop models suitable for basic cell culture to large-scale units used for industrial applications and high-throughput screening. Incubators are indispensable tools in life sciences research, ensuring optimal conditions for the growth and study of biological materials essential for advancing scientific understanding and medical research.

A Humidity Chamber is a specialized laboratory equipment used for creating and maintaining precise humidity levels for various scientific and industrial applications. Here's a brief summary: - **Purpose**: Humidity chambers are designed to provide controlled environments where humidity levels can be adjusted and maintained according to specific experimental or storage requirements. - **Applications**: They are widely used in industries such as pharmaceuticals, electronics, materials science, and food testing to conduct stability studies, simulate environmental conditions, and test product durability under controlled humidity conditions. - **Features**: Typically equipped with digital controls for setting and monitoring humidity levels, temperature regulation systems, and sometimes CO2 controls for more complex environmental simulations. - **Types**: Available in various sizes and configurations, from small benchtop units to large walk-in chambers, to accommodate different sample volumes and experimental needs. - **Importance**: Essential for ensuring product quality, reliability, and safety in research and industrial processes that are sensitive to humidity variations. In essence, humidity chambers play a crucial role in maintaining consistent environmental conditions for testing, research, and storage across a range of scientific disciplines and industrial applications.

The Cook's Pole Climbing Test apparatus is used in behavioral pharmacology research to assess the cognitive and motor responses of rodents, typically rats and mice, to various stimuli. This test is particularly useful for evaluating learning, memory, and the effects of neuroactive drugs, especially those with potential anxiolytic, antipsychotic, and antidepressant properties. Here's how it is used and its significance: Primary Uses of Cook's Pole Climbing Test Assessment of Learning and Memory: Active Avoidance Learning: The Cook's Pole Climbing Test is designed to measure active avoidance learning. In this test, rodents learn to associate a conditioned stimulus (such as a light or tone) with an impending aversive stimulus (usually a mild electric shock delivered to the grid floor). To avoid the shock, the rodent must climb a pole positioned in the test chamber. Training and Testing: During training sessions, the rodent learns to climb the pole upon presentation of the conditioned stimulus to avoid the shock. In subsequent testing sessions, the latency to climb the pole in response to the conditioned stimulus is measured to assess learning and memory retention. Evaluation of Cognitive Enhancers and Impairments: Cognitive Enhancers: The test is used to evaluate the efficacy of cognitive enhancers or nootropic drugs. Improved performance, indicated by reduced latency to climb the pole and increased avoidance responses, suggests enhanced cognitive function. Cognitive Impairments: Conversely, the test can be used to model and study cognitive impairments induced by factors such as neurodegenerative diseases, aging, or drug treatments. Increased latency and decreased avoidance responses indicate cognitive deficits. Pharmacological Testing: Antipsychotic and Anxiolytic Drugs: The Cook's Pole Climbing Test is particularly valuable for testing the effects of antipsychotic and anxiolytic drugs. Antipsychotic drugs may enhance the learning process and decrease avoidance latency, reflecting their potential therapeutic effects. Dose-Response Studies: Researchers use the test to conduct dose-response studies, determining the optimal dosage and efficacy of various pharmacological agents. Studying Neurotransmitter Systems: The test helps in understanding the role of different neurotransmitter systems (e.g., dopaminergic, cholinergic) in learning and memory. By administering receptor-specific agonists or antagonists, researchers can investigate how these systems influence cognitive functions. Behavioral Phenotyping: The Cook's Pole Climbing Test is used for behavioral phenotyping of genetically modified rodents. This helps in identifying the effects of specific genes on learning and memory, contributing to the understanding of genetic influences on cognitive functions. Modeling Psychiatric and Neurological Disorders: The test is used to model psychiatric and neurological disorders such as schizophrenia, anxiety disorders, and Alzheimer's disease. Changes in avoidance behavior can provide insights into the pathophysiology of these conditions and the potential therapeutic effects of drugs. Procedure Overview Apparatus Setup: The Cook's Pole Climbing Test apparatus consists of a chamber with a grid floor that can deliver mild electric shocks and a central pole that the rodent can climb. The rodent learns to climb the pole to avoid the shock. Testing Sessions: In testing sessions, the conditioned stimulus is presented without the shock, and the rodent's latency to climb the pole is recorded. This measures the rodent's learning and memory of the avoidance response. Data Analysis: The latency to climb the pole, number of successful avoidances, and other behaviors are analyzed to assess the cognitive and motor responses of the rodent.

14 stages diffusion cell apparatus having 14 stages means user can place at the same time 14 diffision cell, in addition to 14 stages our apparatus having semi tuto sampling system which gives user friendly sampling without any hectic work, to avoid introduction of air bubbles in the media of receptor cell

Digital friability test apparatus for pharmaceutical laboratories.

MILTON ENTERPRISES introduces Rotarod Apparatus is used to screen effect of drug on motor co-ordination in small laboratory rodent, rotarod consist of five separate compartments, each compartment having separate reset push button, in addition to Reset all one button for reset all frozen timer, Start button to start rotation of central rod, below of floor lip switch has given, when the rodent fall down on the floor flap lip switch touches each other & time in 9999.9 sec. RPM of moving rod will display onscreen it will increase or decrease by up side arrow & downside arrow will freeze on the graphical display for each compartment, also we provide software utility which is optional

Laboratory Enterprises Manufacturing reinvented Laboratory Enterprises manufacture Advanced grip strength meter for scientific study of muscles strength of small laboratory animals such as Rat and Mice, which having capacity up to 50 Newton, user can observer results in Kilograms (Kg), Pounds (lb) and Newton (N), User can change direction of Displayed Reading as it can be from front side and from back side, In addition to this user can freeze maximum reading by pressing Peak mode here user has to press zero to go for next reading. also user can go for Auto peak, by selecting Auto peak mode user will get highest peak results on display for the moment and after 3 seconds grip strength meter will be zero automatic, battery backup facility also provided with the grip strength meter by default, instrument can be directly to the printer also but laboratory Enterprises has provided special software utility for more study as user can view reading on computer screen with numerical and graphical form, also user can export data in micro-soft excel sheet. user can save that experiment re open. Quality Testing Unit, Warehouse, Packaging Unit and Logistics Unit. We have compartmentalized our infrastructure as per the functionalities to bring forth highly reliable and cost effective Pharmacology and Pharmaceutics.

Laboratory Enterprises manufacture and supply advanced Tablet Hardness Tester for the use to many pharmaceutical colleges, medical colleges and advanced research institutes. The level of hardness can be displayed in three different units which can be chosen according to the needs. There is a backup power facility to keep the device running in the case of power failure. Automatic peak point calculation has been enabled to find breaking point of tablet automatically.

Laboratory enterprises introduces advanced tablet hardness tester, which having three kind of unit to display result as per select by user as Kg / Ib / N, battery backup facility provided to avoid interruption in experiment due to electricity failure, without peak and auto peak facility has provided to get break point of tablet automatically, dual sided screen resolution provided to comfort to see from front end and back end to user, in addition to all these features Laboratory enterprises provides PC connectivity but it is optional by this facility user can configure Tablet Hardness Tester instrument